The Amyloid
Proteins of Alzheimer's Disease as Potential Targets
for Drug Therapy, Part 3
Claudio B. Caputa and Andre I. Salama
Department of Pharmacology
ICI Pharmaceuticals Group ICI Americas Inc.
Wilmington, DE 19897
Received 21 February 1989
References
- Abraham, C.R.; Selkoe, D.J.; Potter,
H. Imunochemical identification of the serine protease
inhibitor of 1-antichymotrysin in the brain amyloid
deposits of Alzheimer's disease. Cell 52: 487-501;1998.
- Adiachi, N.; Koh, C.S.; Tsukada,
N.; Shoji, S.; Yanagisawa, N. Invitro degradation
of amyloid material by four proteases in tissue of
a patient with familial amyloidotic polyneuropathy.
J. Neurol. Sci. 84: 295-299; 1988.
- Anonymous. Alpha 1-PI. Drugs of
Today. 24: 279; 1988.
- Anonymous. E-3123. Drugs of the
Future. 13: 613-615; 1988.
- Bartus, R. T.; Dean, R L.; Beer,
B.; Lippa, A.S. The cholinergic hypothesis of geriatric
memory dysfunction. Science 217: 408-417; 1982.
- Bondareff, W. Neurobiolog6y of Alzheimer's
disease. Psychiatr. Annals 14: 179-184; 1984.
- Bowen, D. M.; Smith C. B.; White,
P.; Davison, A. N. Neurotransmitter-related enzymes
and indices of hypoxia in senile dementia and other
abiotrophies. Brain 99: 459-495; 1976.
- Breathnach, S. M. Amyloid and amyloidosis.
J. Am. Acad. Dermatol. 18: 1-16; 1988.
- Caputo, C. B.; MacCallum, D.K.; Kimura,
J. H.; Schrode, J.; Hascall, V.C. Characterization
of fragments produced by clostripain digestion of
proteoglycans from the Swarm rat chondrosarcoma.
Arch. Biochem. Biophys. 20: 220-233; 1980.
- Caputo, C. B.; Shaw, A. Osteroarthritis
as a target for drug intervention, Ann. Reports Med.
Chem. 22: 179-189; 1987.
- Caputo, C. B.; Sygowski, L. A.;
Brunner, W. F.; Scott, C. W.; Salama, A. I. Propterties
of several protein kinases that copurify with rat
spinal cord neurofilaments. Biochim. Biophys. Acta;
in press.
- Caputo, C. B.; Sygowski, L.A.; Patton,
S.P.; Piehl, R.F.; Caccese. R. G.; DiPasquale, G.
Degradation of cartilage-type proteoglycans by a neutral
metalloprotease from rabbit chondrocytes. Connect.
Tissue Res. 18: 191-203: 1988.
- Caputo, C. B.; Sygowski, L.A.; Patton,
S.P. Wolanin, D.J.; DiPasquale, G. Protease inhibitors
decrease cartilage degradation after meniscectomy.
J. Orthop. Res. 6: 103-108; 1988.
- Caputo, C. B.; Sygowski, L. A.;
Wolanin, D. J.; Patton, S.P.; Caccese R.G.; DiPasquale,
G. Effect of synthetic metalloprotease inhibitors
on cartilage autolysis in virtro. J. Pharmacol.
Exp. Ther. 240: 460-465; 1987.
- Caputo, C.B.; Wolanin, D.J.;Roberts,
R.A.; Sygowski, L.A.; Patton, S.P.; Caccese, R.G.
Shaw, A.; diPasquale, G. Proteoglycan degradation
by a chondrocyte metalloprotease: Effects of synthetic
protease inhibitors. Biochem. Pharmacol. 36:
995-1002; 1987.
- Castano, E.M.; Frangione, B. Biology
of disease. Human amyloidosis, Alzheimer disease and
related disorder. Lab. Invest. 58: 122-132;
1988.
- Castano, E.M.;Ghiso, J.;Prelli,
F.; Gorevic, P.D.;Migheli, A.;Frangione, B. In vitro
formation of amyloid fibrils from two synthetic peptides
of different lengths homologous to Alzheimer's disease
B-Protein. Biochem. Biophys. Res. Commun. 41: 782-789.
- Chau, V.; Perry, G.; Friedman, R.
Shaw, G. Ineffective turnover of abnormal proteins
in Alzheimer's disease. Fed. Proc. 46: 21-146;
1987.
- Clark, A.; Parhad, I.;Schoel, M.;
Bazett-Jones, D. Electron microscopic imaging (ESI)
of phosphorous on neurofilaments (nf) and on paired
helical filaments (PHF) of Alzheimer's disease (AD).
Can J. Neurol. Sci. 14; 98-99; 1987.
- Cole. G.M.; Timiras, P.S. Ubiquitin-protein
conjugates in Alzheimer's lesions. Neurosci. Lett.
79: 207-212; 987.
- Coria, F.; Castano, E.M.;Frangione,
B. Brain amyloid in normal aging and cerebral amyloid
angiopathy is antigenically related to Alzheimer's
disease ß- Protein. Am. J. Pathol. 129:
422-428; 1987.
- Coria, F.; Castano, E.; Prelli,
F.; Larrondo-Lillo, M.;Van Duinen, S.; Shelanski,
M.L.; Frangione, B. Isolation and characterization
of amyloid P component from Alzheimer's disease and
other types of cerebral amyloidosis. Lab. Invest.
58: 454-458; 1988.
- Cork. L.C.; Sternberger, N.H. Sternberger,
L.A.; Casanova, M. F,; Struble, R.G.; Price, D.L.
Phosphorylated neurofilament antigens in neurofibrillary
tangles in Alzheimer's disease. J. Neuropathol.
Exp. Neurol. 45: 56-64; 1986.
- Davies, P.; Maloney, A.J.F. Selective
loss of central cholinergic neurons in Alzheimer's
disease. Lancet ii: 1403; 1976.
- Delabar, J. M.; Goldgaber, D.; Lamour,
Y.; Nicole, A.; Huret, J. L.; de Grouchy, J.; Brown,
P.; Gajdusek, D. C; Sinet, P.M. N-amyloid gene duplication
in Alzheimer's disease and karyotypically normal Down
syndrome. Science 235; 1390-1392; 1987.
- Delabar, J.M.; Lamour, Y.; Gegonne,
A.; Davous, P.; Roudier, M.; Nicole, A.;Ceballos,
I.; Amouyel. P.; Stehelin, D.; Sinet, P.M. Rearrangement
of Chromosome 21 in Alzheimer's disease. Ann. Genet.
(Paris) 29: 226-228: 1986.
- Dynan, W. S.; Tjian. R. Control
of eukaryotic messenger RNA synthesis by sequence-specific
DNA-binding proteins. Nature 316; 774-778;
1985.
- Epstein, W. V.; Tan. .; Wood. I.S.
Formation of amyloid fibrils in vitro by action of
human kidney lysosomal enzymes on Bence Jones proteins.
J. Lab. Clin. Med 84: 108-110: 1974.
- Faltz. L.L.; Caputo, C.B.; Kimura,
J.H.;Schrode, J.; Hascall, V. C. Structure of the
complex between byaluronic acid, the hyaluronic acid
binding region and the link protein of proteoglycan
aggregates from the Swarm rat chondrosarcome. J.
Biol. Chem. 254: 1381-1387; 1979.
- Fried, V.A.; Smith, H.T. Ubiquitin;
Its association with specific cellular components
and its active role in cellular events. Alheimer
Disease Assoc. Disorders 2: 188; 1988.
- Furuya, H.; Saski, H.; Goto, I.;
Wong, C.W.; Glenner, C.G.; Sakaki, Y. Amyloid ßProtein
gene duplication is not common in Alzheimer's disease:
Analysis by polymorphic restriction fragments. Biochem.
Biophys. Res. Commun. 150: 75-81; 1988.
- Gandy, S.; Czerik, A.J.; Greengard,
P. Phosphorylation of Alzheimer's disease amyloid
precursor peptide by protein kinase C and Ca²/calmodulin-dependent
protein kinase II. Proc. Natl. Acad. Sci. USA
85: 6218-6221; 1988.
- Ghiso, J.; Jensson, O.; Frangione,
B. Amyloid fibrils in hereditary cerebral hemorrahage
with amyloidosis of Icelandic type is variant of -trace
basic protein (cystatin C). Proc. Natl. Acad. Sci.
USA 83: 2974-2978; 1986.
- Ghiso, J.; Pon-Estel, B.; Frangione,
B. Hereditary cerebral amyloid angiopathy; The amyloid
fibrils contain a protein which is a variant of bystatin
C, an inhibitor of lysosomal cysteine proteases. Biochem.
Biophys. Res. Commun. 136: 548-554; 1986.
- Glenner, G.G. Amyloid deposits and
amyloidosis. The ß-Fibrilloses (First of two
parts). New Enlg. J. Med. 302: 1283-1292;1980.
- Glenner, G.G. Amyloid deposits and
amylodosis. The ß-Fibrilloses (second of two
parts). New Eng. J. Med. 302: 1333-1343; 1980.
- Glenner. G.G.; Eanes. E.D.; Page,
D.L. Creation of "amyloid" fibrils from
Bence Jones proteins in vitro. Science 174:
712-714;1971.
- Glenner, G.G.; Ein, D.; Eanes, E.D.;
Bladen, H.A.; Terry, W.; Page, D.L. Creation of "amyloid"
fibrils from Bence Jones proteins in Vitro. Science.
174: 712-714;1971.
- Glenner, G.G.; Wong, C.W. Alzheimer's
disease: Initial report of the purification and characterization
of a novel cerebrovascular amyloid protein. Biochem.
Biophys. Res. Commun. 120: 885-890.
- Goedert, M.;Wischik, C.M.; Crowther,
R.A.; Walker.J.E.; Klug, A. Cloning and sequencing
of the cDNA encoding a core protein of the paired
helical filament of Alzheimer's disease: Identification
as the microtubule-associated protein tau. Proc.
Natl. Acad. Sci. USA 85: 4051-4055; 1988.
- Goldfinger, S.E. Colchicine for
familial Mediterranean fever. New Engl. J. Med.
287: 1302; 1972.
- Goldgaber, D; Lerman, M.I; McBride,
O.W.; Saffiotti, U.; Gajdusek, D.C. Characterization
and chromosomal localization of a cDNA encoding brain
amyloid of Alzheimer's disease. Science 235;
877-880; 1987.
- Goldgaber, D.; Schmechel, D. E.,
Expression of the amyloid ß-Protein precursor
gene. In: Wurtman, R.J.; Corkin, S.; Growdon,
J.H.; Ritter-Walker, E.,eds. Proc. Fifth Meeting Internat.
Study Group on Pharm. of Memory Disorders Assoc. with
Aging. Cambridge, MA: Center for Brain Sciences and
Metabolism Charitable Trust; 1989: 269-280.
- Goodchild, J.; Agrawal, S.; Civeira.
M.P.; Sarin, P.S.; Sun. D.; Zamecnik, P.C. Inhibition
of human immunodeficiency virus replication by antisense
oligodeoxynucleotides. Pro. Natl. Acad. Sci. USA.
85; 5507-5511; 1988.
- Gottfries, C.G. Neurotransmitters
in the brains of patients with dementia disorders.
Dan. Med. Bull 32 (Suppl.1): 44-48; 1985.
- Green, P.J. ;Pines, O.; Inouye,
M. The role of antisense RNA in gene regulation. Annu.
Rev. Biochem. 55: 569-597; 1986.
- Green, S.; Chambon, P. Oestradiol
induction of a glucocortioid-responsive gene by a
chimaeric receptor. Nature 325: 75-78; 1987.
- Grunkdke-Iqbal. I.; Iqbal, K.; Quinlan,
M.; Tung, Y.: C; Zaidi, M. S.; Wisniewski, H. M. Microtubule-associated
protein tau. A component of Alzheimer paired helical
filaments. J. Biol. Chem. 261: 6084-6089; 1986.
- Grundke-Iqbal. I.; Iqbal,K.; Tung,
Y.C.; Quinlan, M.; Wisniewski, H.M.; Binder, L. I.
Abnormal phosphorylation of the microtubule-associated
protein tau in Alzheimer cytoskeletal pathology. Proc.
Natl. Acad. Sci. USA 83: 4913-4917;1986.
- Guiroy, D.C.; Miyazaki, M.; Multhaup,
G.; Fischer, P.; Garruto, R.M.; Beyreuther, K.; Masters,
C.L.; Simms, G.; Gibbs, C. J.; Gajdusek, D.C. Amyloid
of neurofibrillary tangles of Guamanian parkinsonism-dementia
and Alzheimer disease share identical amino acid sequence.
Proc. Natl. Acad. Sci. USA 84: 2073-2077; 1987.
- Hamazaki, H. Ca2+-mediciated
hemagglutination by serum amyloid P component and
the inhibition by specific glycosaminoglycans. Biochem.
Biophys.Res. Commun. 150: 212-218; 1988.
- Hamazaki, H. Calcium-mediated hemagglutination
by serum amyloid P component and the inhibition by
specific glycosaminoglycans. Biochem.Biophys. Res.
Commun. 150: 212-218; 1988.
- Haugh, M.C.; Probst, A.; Ulrich,
H.; Kahn, J.; Anderton, B.H. Alzheimer neurofibrillary
tangles contain phosphorylated and hidden neurofilament
epitopes. J. Neurol. Neurosurg. Psychiatry
49: 1213-1220; 1986.
- Helander, I.; Hopsu-Havu, V.K. Treatment
of lichen amyloidosis by etretinate. Clin. Exp.
Dermatol. 11: 574-577; 1986.
- Hirano, A.; Malamud, N.; Kurland,
L.T. Parkinsonism-dementia complex, an endemic disease
on the island of Guam. II.--Pathological features.
Brain. 84: 662-679; 1961.
- Ihara,Y.; Nukina, N.; Miura, R.;
Ogawara, M. Phosphorylated tau protein is integrated
into paired helical filaments in Alzheimer's disease.
J. Biochem. 99: 1807-1820; 1986.
- Imahori, K.; Sugita, H.; Miyatake,
T.; Ishihara, T.; Miyatani, N.; Kuwabara, T. Pharmacokinetics
and safety of EST, a new thiol protease inhibitor
in patients with muscle diseases. Jpn. J. Clin.
Pharmacol. Ther. 16: 749-757; 1985.
- Isobe. T.; Osserman, E.F. Effects
of dimethyl sulfoxide (DMSO) on Bence Jones proteins,
amyloid fibrils and casein-induced amyloidosis.
In.: Wegelius, O.; Pasternack, A.; Amyloidosis. New
York: Academic Press; 1976: 247-257.
- Joachim. C.L.; Morris, J.H.; Kosik,
K.S.; Selkoe, D.J. Tau antisera recognize neurofibrillary
tangles in a range of neurodegenantive disorders.
Ann. Neurol. 22: 514-520; 1987.
- Kalman, T.I. Enyme inhibition as
a source of new drugs. Drug Dev. Res. 1: 311-328:
1981.
- Kang. J.; Lemaire, H.G.; Unterbeck,
A.; Salbaum, J.M.: Masters, C.L.; Gzeschik, K.H.;
Multhaup, G.; Beyreuther, K.; Muller-Hill, B. The
precursor of Alzheimer's disease amyloid A4 protein
resembles a cell- surface receptor. Nature.
325: 733-736; 1987.
- Kedar, I. Greenwald, M.; Ravid.
M. Treatment of experimental murine amyloidosis with
dimethyl sulfoxide. Eur. J. Clin. Invest. 7:
149-150; 1977.
- Khokha, R.; Denhardt. D.T. On the
use of anti-sense RNA: down-regulation of mRNA encoding
a metallo-proteinase inhibitor. Anticancer Res.
7: 653-660; 1987.
- Kirschner. D.A.; Abraham, C.; Selkoe,
D. J. X-Ray diffraction from intraneuronal paired
helical filaments and extraneuronal amyloid fibers
in Alzheimer's disease indicates cross-ß conformation..
Proc. Nat. Acad. Sci. USA 83: 503-507: 1986.
- Kirschner, D.A.; Inouye. H. Duffy.
L.K.; Sinclair, A: Lind, M.; Selkoe, D.J. Synthetic
peptide homologous to ß protein from Alzheimer
disease forms amyloid-like fibrils in vitro. Proc.
Natl. Acad. Sci. USA 84: 6953-6957; 1987.
- Kisilevsky, R. From arthritis to
Alzheimer's disease: current concepts on the pathogenesis
of amyloidosis. Can J. Physiol. Pharmacol.
65: 1805-1815; 1987.
- Kitaguchi, N.; Takahaski, Y.; Tokushima.
Y.; Shiojiri, S.; Ito. H. Novel precursor of Alzheimer's
disease amyloid protein shows protease inhibitory
activity. Nature. 331: 530-532; 1988.
- Kosik, K. S.; Duffy, L.K.; Dowling,
M.M.; Abraham, C.; McCluskey, A.; Selkoe, D.J. Microtubule-associated
protein 2; Monoclonal antibodies demonstrate the selective
incorporation of certain epitopes into Alzheimer neurofibrillary
tangles. Proc. Natl. Acad. Sci. USA 81: 7941-7945;
1984.
- Linke, R.P.; Zucker-Franklin, D.;
Franklin, E.C. Morphologic, chemical, and immonologic
studies of amyloid-like fibrils formed from Bence-Jones
proteins by proteolysis. J. Immunol. 111: 10-23;
1973.
- Man. D. M.A. The pathological association
between Down Syndrome and Alzheimer disease. Mech.
Aging. Dev. 43: 99-136; 1988.
- Mann. D.M.A.; Bonshek, R.E.; Marcyniuk,
B.; Stoddart, R.W.; Torgerson, E. Saccarides of senile
plaque and neurofibrillary tangles in Alzheimer's
disease. Neurosci. Lett. 85: 277-282; 1988.
- Mann. D.M.A.; Hardy, J. The importance
of altered structural proteins in the pathogenesis
of Alzheimer's disease. Neurobiol. Aging. 7:
444-446; 1986.
- Masters, C.L.; Beyreuther, K. Protein
abnormalities in neurofibrillary tangles; their relationship
to the extracellular amyloid deposits of the A4 protein
in Alzheimer's disease. In: Wurtman, R.J.; Corkin,
S.;Growdon, J.H.; Ritter-Walker. E., eds. Proc. Fifth
Meeting Internat. Study Group on Pharm. of Memory
Disorders Assoc. with Aging. Cambridge, MA: Center
for Brain Sciences and Metabolism Charitable Trust:
1989: 235-268.
- Masters.; C.L.; Multhaup. G.; Pottgiesser,
J.; Martins, R.N.; Beyreuther, K. Neuronal origin
of a cerebral amyloid; neurofibrillary tangles of
Alzheimer's disease contain the same protein as the
amyloid of plaque cores and blood vessels. EMBO
J. 4: 2757-2763; 1985.
- Masters. C.L.; Simms, G.; Weinman,
N. A.; Multhaup, G.; McDonald, B.L.; Beyreuther, K.
Amyloid plaque core protein in Alzheimer disease and
Down syndrome. Proc. Natl. Acad. Sci. USA 82: 4245-4249;
1985.
- Matsukura, M.; Shinozuka, K.; Zon,
G.; Mitsuya. H.; Reitz, M.; Cohen, J.S.; Broder, S.
Phosphorothioate analogs of oligodeoxy-nucleotides;
Inhibitors of replication and cytopathic effects of
human immunodeficiency virus. Proc. Natl. Acad.
Sci. USA 84: 7706-7710; 1987.
- Matus. A.; Green, G.D.J. Age-related
increase in cathepsin D like protease that degrades
brain microtubule-associated proteins. Biochemistry.
26: 8083-8086; 1987.
- Mesulam. M. --M. Shift in patterns
of cerebrocortical cholinesterases in Alzheimer's
disease: Implications for pathogenesis, diagnosis,
and treatment. In: Wurtman R.J. Corkin, S.; Growdon,
J.H.; Ritter-Walker, E. eds. Proc. Fifth Meeting Internat.
Study Group on Pharm. Of Memory Disorders Assoc. with
Aging. Cambridge, MA: Center for Brain Sciences and
Metabolism Charitable Trust; 1989: 373-378.
- Miller, C.C.J.; Anderton, B.H. Transglutaminase
and the neuronal cytoskeleton in Alzheimer's disease.
J. Neurochem. 46: 1912-1922: 1986.
- Mitsuya, H.; Jarrett, R.F.; Matsurkura,
M.; Veronese. F.D.; DeVico, A.L.; Sarngadharan, M.G.;
Johns, D.G.; Reitz, M.S.; Broder, S. Long- term inhibition
of human T-lymphotropic virus type III/lymphadnenopathy-associated
virus (human immunodeficiency virus) DNA synthesis
and RNA expression in T cells protected by 2', 3'
-dideoxynucleosides in vitro. Proc. Natl. Acad.
Sci. USA 84: 2033-2037; 1987.
- Miyahara, T.; Shimojo; S.; Toyohara,
K.; Imai, T.; Miyajima, M.; Honda, H.; Kamegai, M.;
Ohzeki, M.; Kokatsu, J. Phase I study of EST, a new
thiol protease inhibitor--The second report: Safety
and pharmacokinetics in continuous administration.
Jpn. J. Clin. Pharmacol. Ther. 16: 537-546;
1985.
- Mobley. W.C.; Neve, R.L.; Prusiner,
S.B.; McKinley, M.P. Nerve growth factor increases
mRNA levels for the prior protein and the B-Amyloid
protein precursor in developing hamster brain. Proc.
Natl. Acad. Sci. USA 85: 9811-9815; 1988.
- Neve. R.L. Selkoe, D.J.; Kurnit,
D.M.; Kosik. K.S. A cDNA for a human microtubule associated
protein 2 epitope in the Alzheimer neurofibrillary
tangle. Mol. Brain. Res. 1: 193-196; 1986.
- Nukina, N. Ihara. Y. One of the
antigenic determinants of paired helical filaments
is related to tau protein. J. Biochem. 99:
1541-1544; 1986.
- Nukina, N.; Kosik. K.S.; Selkoe,
D.J. Recognition of Alzheimer paired helical filaments
by monoclonal neurofilament antibodies is due to crossreaction
with tau protein. Proc. Natl. Acad. Sci. USA
84: 3415-3419; 1987.
- Perry. E.K.; Perry, R.H.; Blessed.
G.; Tomlinson, B.E. Necropsy evidence of central cholinergic
deficits in senile dementia. Lancet 1: 189;
1977.
- Perry, E.K.; Tomlinson, B.E.; Blessed,
G.; Bergmann, K.; Gibson, P.H.; Perry, R.H. Correlation
of cholinergic abnormalities with senile plaques and
mental test scores in senile dementia. Br. Med.
J. 2: 1457-1459; 1978.
- Petrillo. E.W.; Ondetti. M. A. Angiotensin-converting
enzme inhibitors; Medicinal chemistry and biological
actions. Med. Res. Rev. 2: 1-41; 1982.
- Podisny, M.B. Lee, G.; Selkoe, D.J.
Gene dosage of the amyloid ß precursor protein
in Alzheimer's disease. Science 238: 669-672.
- Ponte, P.: Gonzalez-DeWhitt, P.;
Schilling, J.; Miller; Hsu, D.; Greenberg, B,; Davis,
K.; Wallace,; W.; Lieberburg, I.; Fuller, F.;Corderll,
B. A new A4 amyloid mRNA contains a domain homologous
to serine proteinase inhibitors. Nature. 331:
525-527; 1988.
- Prelli, F.; Castano, E.; Glenner,
G. G.; Frangione, B. Differences between vascular
and plaque core amyloid in Alzheimer's disease. J.
Neurochem. 51: 648-651; 1988.
- Prelli, F.; Castano, E.M.; Van Duinen,
S.G.; Bots, G.T.A.M.; Luyendijk, W.; Frangione, B.
Different processing of Alzheimer's B-protein precursor
in the vessel wall of patients with hereditary cerebral
hemorrhage with amyloidosis-Dutch type. Biochem.
Biophys. Res. Commun. 151: 1150-1155; 1988.
- Probst. A.; Brunnschweiler, H.;
Lautenschlager, C.; Ulrich, J.A. special type of senile
plaque, possibly an initial stage. Acta Neuropathol.
(Berl) 74;133-141; 1987.
- Ravid, M.; Robson, M.; Kedar, I.
Prolonged colchicine treatment in four patients with
amyloidosis. Ann. Intern. Med. 87: 568-570;
1977.
- Robakis, N.K.; Ramakrishna, N.;
Wolfe, G.; Wisniewski, H.M. Molecular cloning and
characterization of a cDNA encoding the cerebrovascular
and the neuritic plaque amyloid peptides. Proc.
Natl. Acad. Sci; USA 84: 4190-4194; 1987.
- Roses, A.D.; Pericak-Vance, M.A.;
Haynes, C.S.; Haines, J.L.; Gaskell, P.A.; Yamaoka,
L.; Hung, W-Y.; Heyman, A.L.; Clark, C.M. Linkage
analysis in late onset familial Alzheimer's disease
(AD). Ninth International Workshop on Human Gene Mapping.
Cytogenet. Cell Genet. 46: 684; 1987.
- Roth. M. The association of clinical
and neurobiological findings and its bearing on the
classification and etiology of Alzheimer's disease.
Br.Med. Bull. 42: 42-50; 1986.
- Seitoh, T.; Hansen, L.A.; Dobkins,
K.R.; Terry, R. D. Increase Mr 60,000 protein phosphorylation
is correlated with neocortical neurofibrillary tangles
in Alzheimer's disease. J. Neuropathol. Exp. Neurol.
47: 1-8; 1988.
- Salbaum, J.M.; Weidmann, A.; Lemaire,
H.G.; Masters, C.L.; Beyreuther, K. The promotor of
Alzheimer's disease amyloid--A4 precursor gene. EMBO
J. 7;502-502; 1986.
- Saper, C.B. Which came first, the
neuritic plaque or the neurofibrillary tangle? Neurobiol.
Agineg 7: 502-503; 1986.
- Saper, C.B. German, D.C.; White.
C.L. Neuronal pathology in the nucleus basalis and
associated cell groups in senile dementia of the Alzheimer
type: Possible role in cell loss. Neurology 35:
1089-1095; 1985.
- Sashida, H.; Abiko, Y. Inhibition
by NCO-700, a protease inhibitor of degradation of
cardiac myofibrillar proteins during ischemia in dogs.
Biochem. Pharmacol. 34: 3875-3889; 1985.
- Sayre, L.M.; Autilio-Gambetti,
L.; Gambetti, P. Pathogenesis of experimental giant
neurofilamentous axonopathies: A unified hypothesis
based on chemical modification of neurofilaments.
Brain Res. Rev. 10: 69-83; 1985.
- Schellenber, G.D.; Bird, T.D.;
Wijsman, E.M.; Moore, D.K.; Boehnke, M.; Bryant, E.M.;
Lampe, T.H.; Nochlin, D.; Sumi, S. M. Deeb, S.S.;
Beyreuther, K.; Martin, G.M. Absence of linkage of
chromosome 21q21 markers of familial Alzheimer's disease.
Science 241;157-1510. 1988.
- Schubert, D.; Schroeder, R.; LaCorbiere,
M.; Saitoh, T.; Cole, G. Amyloid B protein precursor
is possibly a heparan sulfate proteoglycan core protein.
Science 241: 223-226; 1988.
- Scott, C.W.; Salama, A.I.; Caputo,
C.B. Phosphorylation of tau protein by glycogen synthase
kinase-3. Fed. Proc. in press.
- Seldoe, D.J. Altered structural
proteins and tangles; What do they tell us about the
biology of Alzheimer's disease: Neurobio. Aging
7: 425-431; 1986.
- Selkoe, D.J. Deciphering Alzheimer's
disease: the pace quickens. Trends Neurosci,
10: 181-184; 1987.
- Selkoe, D.J.; Abraham, C.; Ihara,
Y. Brain transglutaminase: In vitro crosslinking of
human neurofilament protein into insoluble polymer.
Proc. Natl. Acad. Sci. USA 79: 6070-6074;
1982.
- Selkoe, D.J.; Ihara, Y.; Salazar,
F.J. Alzheimer's disease: Insolubility of partially
purified paired helical filaments in sodium dodecyl
sulfate and urea. Science 215: 1243-1245; 1982.
- Selkoe, D.J.; Podlisny, M.B.; Gronbeck,
A.; Mammen, A.; Kosik. K.S. Molecular relation
of amyloid filaments and paired helical filaments
in Alzheimer's disease. In: Wurtman, R. J.; Corkin,
S.; Growdon. J.H.; Ritter-Walker. E. eds.. Proc. Fifth
Meeting Internat. Study Group on Pharm. Of Memory
Disorders Assoc. with Aging. Cambridge, MA: Center
for Brain Sciences and Metabolism Charitable Trust;
1989: 281-296.
- Shirhama, T.; Benson, MD; Cohen,
A.S. Tanaka, A. Fibrilllar assemblage of variable
segments of immunoglobulin light chains: an electron
microscopic study. J. Immunol. 10;21-30; 1973.
- Skinner, M. Stone, P.; Shirhama,
T.; Connors, L.H.; Calore, J.; Cohen, A.S. The association
of an elastase with amyloid fibrils. Proc Soc.
Biol. Med 181;211-214; 1986.
- Smith, C. C.; Aurelian, L.; Reddy,
M.P.; Miller, P.S.; Ts'o, P. O. P. Antiviral effect
of an oligo (nucleoside methylphosphonate) complementary
to the splice junction of herpes simplex virus type
1 immediate early pre-mRNAs 4 and 5. Proc. Natl.
Scie. USA. 83: 2787-2791; 1986.
- Snow. A.D.; Willmer. J.: Kisilevsky,
R. Sulfated glycosaminoglycans; A common constituent
of all amyloids? Lab. Inves. 56: 120-123; 1987.
- Snow. A.D.; Willmer, J. P.; Kisilevsky,
R. Sulfated glysaminoglycans in Alzheimer's disease.
Hum. Pathol. 18: 506-510; 1987.
- St. George-Hyslop, P.H.; Tanzi,
R.E.; Polinsky, R.J. Neve, R. L. et.al. The
genetic defect causing familial Alzheimer's disease
maps on chromosome 21. Science 235: 885-890;
1987.
- St. George-Hyslop, P.H.; Tanzi,
R. E.; Polinsky R.J. Neve, R. L., et. al. Absence
of duplication of chromosome 21 genes in familial
and sporadic Alzheimer's disease. Science 238:
664-666; 1987.
- Sternberger, N.H.; Sternberger,
L.A.; Ulrich, J. Aberrant neurofilament phosphorylation
in Alzheimer disease. Proc. Natl. Acad. Sci. USA.
82: 274-276; 1985.
- Struble. R.G.; Hedreen, J.C.; Cork.;
L.C.; Price, D.L. Acetylcholinesterase activity in
senile plaques of aged macques. Neurobiol. Aging
5: 191-198; 1984.
- . Struhl. K. Promoters, activator
proteins, and the mechanism of transcriptional initiation
in yeast. Cell 49: 295-297; 1987.
- Sumpter, P.Q.; Mann. D.M.A.; Davies,
C.A.; Yates, P.O.; Snowden, J.S.; Neary, D. An ultrastructural
analysis of the effects of the cerebral cortex in
Alzheimer's disease. Neuropathol. Appl. Neurobiol.
12: 305-319; 1986.
- Suzuki, H.; Takeda, M.; Kato, Y.;
Yamashita, T.; Tada, K.; Hariguchi, S.; Nishimura,
T. Cathepsin D activities in dementia brains and the
degradation of neurofilament proteins with cathepsin
D. Neurochem. Res. 13: 264; 1988.
- Tanzi, R.E.; Gusella, J.F.; Watkins,
P.C.; Bruns, G.A.P.; St. George-Hyslop, P.; Van Keuren,
M.L.; Patterson, D.; Pagen, S.; Kurnit, D.M.; Neve,
R.L. Amyloid B protein gene is not duplicated in brains
from patients with Alzheimer's disease. Science
238: 666-669; 1987.
- Tanzi, R. E.; Gusella, J. F.; Watkins,
P.C.; Burns, G.A.P.; St. George-Hyslop, P.; Van Keuren,
M. L.; Patterson, D.; Pagan, S.; Kurnit, D. M.; Neve,
R. L. Amyloid ß protein gene: cDNA, mRNA distribution,
and genetic linkage near the Alzheimer locus. Science
235: 880-884; 1987.
- Tanzi, R.E.; Mc Clatchey, A. I.;
Lamperti, E. D.; Villa-Komaroff, L.; Gusella, J. F.;
Neve, R. L. Protease inibitor domain encoded by any
amyloid protein precursor mRNA associated with Alzheimer's
disease. Nature 331: 528-530; 1988.
- Tanzi, R. E.; St. George-Hyslop.
P. H.; Haines, J. L.; Polinsky, R. J., et al.
The genetic defect in familial Alzheimer's disease
is not tightly linked to the amyloid B-protein gene.
Nature 329: 156-157; 1987.
- Tape, C.; Tan, R.; Nesheim. M.;
Kisilevsky, R. Is proteolytic attack on amyloid precursor
proteins a pre or post fibrilogenic event? Lab.
Invest. 58: 92A; 1988.
- Terry, R. D.; Hansen, L..A.; DeTeresea,
R.; Davies, P.; Tobias, H.; Katzman, R. Senile dementia
of the Alzheimer type without neocortical neurofibrillary
tangles. J. Neuropathol. Exp. Neurol. 46: 262-268;
1987.
- Tomlinson. B.E. Plaques, tangles,
and Alzheimer's disease. Psychol. Med. 12:
449-459; 1982.
- Van Broeckhoven. C.; Genthe, A.
M.; Vandenberghe, A.; Horsthemke, B., et al.
Failure of familial Alzheimer's disease to segregate
with the A4-amyloid gene in several European families.
Nature 329: 153-155; 1987.
- Van Duinen. S. G.; Castano, E.
M.; Prelli, F. Bots. G. T. A. B.; Luyendijk, W.; Frangione,
B. Hereditary cerebral hemorrhage with amyloidosis
in patients of Dutch origin is related to Alzheimer
disease. Proc. Natl. Acad. Sci. USA. 84: 5991-5994;
1987.
- . Wharton. R. P.; Brown, E. L.;
Ptashne, M. Substituting an a-helix switches the sequence-specific
DNA interactions of a repressor. Cell 38: 361-369;
1984.
- . Wharton, R. P. ; Ptashne, M. Changing
the binding specificity of a repressor by redesigning
an a-helix. Nature 316: 601-605; 1985.
- Wilcock, G. K. Esiri, M. M. Plaques,
tangles, and dementia. A quantitative study. J.
Neurol. Sci. 56: 343-356; 1982.
- Wischik, C. M.; Novak, M.; Edwards,
P. C.; Klug, A.; Tichelaar. W.; Crowther, R. A. Structural
characterization of the core of the paired helical
filament of Alzheimer's disease. Proc. Natl. Acad.
Sci. USA 85: 4884-4888; 1988.
- Wischik, C. M.; Novak, M.; Thogersen,
H,C.; Edwards, P. C.; Runswichk, M. J.; Jakes, R.;
Walker, J. E.; Milstein, C.; Roth, M.; Klug. A. Isolation
of a fragment of tau derived from the core of the
paired helical filament of Alzheimer's disease. Proc.
Natl. Acad. Sci. USA 85: 4506-4510; 1988.
- Wisniewski, H. M.; Currie, J. R.;
Barcikowska, M.; Robakis, N. K.; Miller, D. L. Alzheimer's
disease, a cerebral form of amyloidosis. In: Pouplard-Bartelaix.
A.; Emile, J.; Christen, Y., eds. Immunology and Alzheimer's
disease. Paris: Springer-Verlag; 1988;1-6.
- Wisniewski, H. M.; Sinatra, R.
S.; Iqbal, K., Grundke-Iqbal, I. Neurofibrillary
and synaptic pathology in the aged brain. In:
Johnson. J. E., Jr., ed. Aging and cell structure,
vol. 1. New York; Plenum Publishing corp: 1981: 105-141.
- . Woog, C. W.; Quaranta, V.; Glenner,
G. G. Neuritic plaques and cerebrovascular amyloid
in Alzheimer disease are antigenically related. Proc.
Natl. Acad. Sci. USA 82: 8729-8732; 1985.
- Wood, J.G.; Mirra, S. S.; Pollack,
N. J. Binder, L. I. Neurofibrillary tangles of Alzheimer
disease share antigenic determinants with the axonal
microtubule-associated protein tau, (t). Proc.
Natl. Acad. Sci. USA 83: 4040-4043; 1986.
- Yanker, B. A.; Dawes, L. R.; Fisher,
S.; Villa-Komaroff, L.; Granite, M.L.; Neve, R. L.
Neurotoxicity of a fragment of the precursor associated
with Alzheimer's disease. Science417-140.1989.
- S. H.; Dickson. D. W.; Crowe. A.;
Butler, M,; Shelanski, M. L. Alzheimer's neurofibrillary
tangles contain unique epitopes and epitopes in common
with the heat-stable microtubule assoicated proteins
tau and MAP 2. Am J. Pathol. 126: 81-91; 1987.
- Yen, S. H.; Gaskin, F.; Fu, S.
M. Neurofibrillary tangles in senile dementia of the
Alzheimer's type share an antigenic determinant with
intermediate filaments of the vimentin class. Am.
J. Pathol. 113: 373-381; 1983.
- Young. I. D.; Kisilevsky, R. Ultrastructural
localization of glycosaminoglycans in amyloid deposits
of Alzheimer's disease. Lab. Invest. 58: 107A;1988.
- Zappia. V.; Galletti, P.; Porta,
R.; Wold, F. Advances in posttranslational modifications
of proteins and aging. New York: plenum Press; 1988.
(Adv. Exp. Med. Biol. vol. 231).
- . Zebrower, M.; Beeber, C.; Kieras.
F. J. Proteoglycan synthesis in Alzheimer's disease
fibroblasts. Age 10: 164; 1987.
- Zhang, H.; Sternberger, N.; Herman,
M.; Robinstein, L.; Binder, L.; Sternberger, L. Abnormal
processing of multiple proteins in Alzheimer's disease
(AD). J. Neuropathol. Exp. Neurol. 47: 319;1988.
Source: This article was printed in "Microbiology of
Aging, Vol. 10, pp. 451-461. ŠPergamon Press pic. 1989.
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