Dimethyl Sulfoxide (DMSO) - Dr. Stanley Jacob



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Welcome to the Dimethyl Sulfoxide (DMSO) information center. Select one of the links above for additional information about this versatile treatment option.

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Dr. Griffith spent years mentoring with Dr. Jacob and uses DMSO daily in his private medical practice.

“Father of DMSO” Passes at 91

Dr. Stanley Jacob, my friend, mentor and the “Father of DMSO”, passed away January 17th, 2015 ten days after celebrating his 91st birthday with friends and family. The first time I met Stanley was in 2006 over the phone when he called me at 5 am after I had sought him out to learn more about DMSO from the world’s indisputable foremost authority. Stanley was in his mid 80’s at the time and he apologized for waking me but explained that he had to call early because he would be spending the entire day hard at work and would not be able to take a break later in the day – he always called me at 5 am thereafter. >>Read full article

As many of you know, we have been involved with DMSO research for almost a half a century.
The literature on this agent is voluminous. There are just shy of 1 million scientific articles. We will post a few
new articles of the most important research findings every 2 weeks. Please check back often for the new postings.

An Alternative Mechanism for Radioprotection by Dimethyl Sulfoxide;
Possible Facilitation of DNA Double-strand Break Repair
Genro KASHINO, Yong LIU, Minoru SUZUKI, Shin-ichiro MASUNAGA,Yuko KINASHI, Koji ONO, Keizo TANO and Masami WATANABE

Dimethyl sulfoxide/Indirect action/NHEJ/Oxidative stress.
The radioprotective effects of dimethyl sulfoxide (DMSO) have been known for many years, and the suppression of hydroxyl (OH) radicals induced by ionizing radiation has been thought to be the main cause of this effect. However, the DMSO concentration used was very high, and might be toxic, in earlier studies. In the present study, we administered a lower, non-toxic concentration (0.5%, i.e., 64 mM) of DMSO before irradiation and examined its radioprotective effects.

Methyl Sulfone Induces Loss of Metastatic Properties and Reemergence of Normal Phenotypes in a Metastatic Cloudman S-91 (M3) Murine Melanoma Cell Line
Joan McIntyre Caron, Marissa Bannon, Lindsay Rosshirt, Jessica Luis, Luke Monteagudo, John M. Caron, Gerson Marc Sternstein Department of Cell Biology, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut, United States of America

Abstract
Background: The most deadly form of cancer is not lung or colon, breast or prostate; it is any cancer that has become metastatic. Mortality due to metastatic melanoma, one of the most aggressive and deadly cancers, has increased steadily over the last several decades. Unfortunately, the arsenal of chemotherapeutic agents available today is most often unsuccessful at extending and improving the life expectancy of afflicted individuals. We sought to identify an effective and nontoxic agent against metastatic melanoma.


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